Background: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. This gene encodes diazepam binding inhibitor, a proteinthat is regulated by hormones and is involved in lipid metabolismand the displacement of beta-carbolines and benzodiazepines, whichmodulate signal transduction at type A gamma-aminobutyric acidreceptors located in brain synapses. The protein is conserved fromyeast to mammals, with the most highly conserved domain consistingof seven contiguous residues that constitute the hydrophobicbinding site for medium- and long-chain acyl-Coenzyme A esters.Diazepam binding inhibitor is also known to mediate the feedbackregulation of pancreatic secretion and the postprandial release ofcholecystokinin, in addition to its role as a mediator incorticotropin-dependent adrenal steroidogenesis. Three pseudogeneslocated on chromosomes 6, 8 and 16 have been identified. Multipletranscript variants encoding different isoforms have been describedfor this gene. [provided by RefSeq, Jul 2008].
Description: Rabbit polyclonal to ACBD
Immunogen: KLH conjugated synthetic peptide derived from ACBD
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 10 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
