Background: Cell cycle progression is controlled, in part, by a family of cyclin-dependent kinases (Cdks) that work to phosphorylate key substrates involved in each phase of cell cycle progression. Cdks are the catalytic subunits of serine/threonine protein kinases, a large family of proteins that act as regulators of the eukaryotic cell cycle. Cdk11 (cyclin-dependent kinase 11), also known as CDC2L6 (cell division cycle 2-like 6 (CDK8-like)), is a 502 amino acid protein that contains one protein kinase domain and functions to catalyze the ATP-dependent transfer of phospho residues to target substrates. Additionally, Cdk11 exists as a component of the mediator coactivator complex, suggesting a role in transcriptional activation. Multiple isoforms of Cdk11 exist due to alternative splicing events. The gene encoding Cdk11 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome.
Description: Rabbit polyclonal to CDC2L6
Immunogen: KLH conjugated synthetic peptide derived from CDC2L6
Specificity: ·Reacts with Human, Mouse, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 57 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
