Background: CD2 family proteins are encoded by genes near the centromere of the long and short arms of chromosome 1. The growing CD2 family consists of Ig domain-containing cell surface proteins involved in lymphocyte activation and/or adhesion via extracellular and cytoplasmic domains. B lymphocyte activator macrophage expressed (BLAME), also designated Slam family member 8 (SLAMF8), is a 285-amino acid CD2 family protein that contains a leader sequence, a 31-residue cytoplasmic tail, and a 212-amino acid extracellular domain that has an N-terminal IgV-like fold without disulfide bonds and a membrane proximal C2-like fold. BLAME may be involved in B-lineage commitment and/or regulation of signaling through the B-cell receptor. It localizes to the membrane and is expressed in lymph node, thymus, bone marrow and spleen. The human BLAME protein is 75% identical to the mouse BLAME protein.
Description: Rabbit polyclonal to SLAMF8
Immunogen: KLH conjugated synthetic peptide derived from SLAMF8
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 32 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
