Background: The endophilins comprise a family of proteins that associate with Amphi-physin, Synaptojanin and Dynamin and are implicated in presynaptic vesicle trafficking at nerve terminals. The expression patterns of the endophilins are consistent with their cellular functions at the neuronal synapse. Endophilin B1 is a member of the B subgroup of the endophilin family that is required for maintenance of mitochondrial morphology and for the regulation of the outer mitochondrial membrane dynamics. The N-terminal domain of Endophilin B1 shares highest similarity with the lipid-binding and -modifying (LBM) domain of class A endophilins. The Endophilin B1 gene encodes at least three splice variants: Endophilin B1a, which shows a widespread tissue distribution, and Endophilin B1b and B1c, which appear to be brain-specific.
Description: Rabbit polyclonal to Bif
Immunogen: KLH conjugated synthetic peptide derived from Bif
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
