Background: RNH1, the placental ribonuclease (RNase) inhibitor, is an acidic 460-amino acid protein which contains an unusually high content of leucine and cysteine residues. It is a member of a family of proteinaceous cytoplasmic RNase inhibitors that are expressed in many tissues and bind to both intracellular and extracellular RNases in the cytosol. RNH1 binds to a diverse variety of mammalian RNases and holds them in a latent form. It is also important in the control of mRNA turnover. RNH1inhibits angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily. Because angiogenesis is necessary for the growth and metastasis of tumors, RNH1 may play an important role in cancer gene therapy.
Description: Rabbit polyclonal to Ribonuclease Inhibitor
Immunogen: KLH conjugated synthetic peptide derived from Ribonuclease Inhibitor
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 50 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
