Background: PHF8 (PHD finger protein 8), also known as JHDM1F (Jumonji C domain-containing histone demethylase 1F), MRXSSD or ZNF422, is a 1,024 amino acid protein belonging to the PHD finger protein family. Members of the PHD finger protein family function as transcriptional regulators that affect gene expression by modulating chromatin structure. PHF8 is an evolutionarily conserved protein containing one PHD-type zinc finger and one JMJC domain, suggesting a possible role for PHF8 in transcription regulation and chromatin remodeling. Mutations in the gene encoding PHF8 can result in MRXSSD (mental retardation X-linked Siderius type), a condition characterized as a syndromic form of mental retardation in which patients may exhibit recognizable physical signs such as facial dysmorphy or skeletal abnormalities or biochemical abnormalities.
Description: Rabbit polyclonal to PHF8
Immunogen: KLH conjugated synthetic peptide derived from PHF8
Specificity: ·Reacts with Human, Mouse, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 118 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
