Background: The oligodendrocyte lineage-specific basic helix-loop-helix (Olig) family of transcription factors include Olig1-Olig3, which differ in tissue expression. Olig1 and Olig2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. Olig2 is more widely expressed in embryonic brain than Olig1, while Olig3 is primarily expressed in non-neural tissues. Olig1 and Olig2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between Olig proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development.
Description: Rabbit polyclonal to Olig2
Immunogen: KLH conjugated synthetic peptide derived from Olig2
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 32 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
