Background: The interleukins (ILs) are a broad family of well characterized cytokines, primarily of hematopoietic cell origin. They are secreted by immune cells (mainly macrophages, B-cells or T-cells) that regulate a wide range of immune system functions. The specific functions of different interleukins vary from the regulation of inflammatory and immune responses to the regulation of other interleukins. IL-34 (interleukin-34) is a 235 amino acid secreted mouse protein that belongs to the interleukin family of cytokines. Existing as a homodimer, IL-34 functions to promote the viability and differentiation of macrophages and monocytes and may also act as a ligand for c-Fms/CSF-1R, a colony-stimulating factor. Multiple alternatively spliced isoforms of IL-34 exist, all of which are encoded by a gene that maps to mouse chromosome 8.
Description: Rabbit polyclonal to IL34
Immunogen: KLH conjugated synthetic peptide derived from IL34
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 27 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
