Background: Trichoplein, also known as THCP (trichoplein keratin filament-binding protein) or mitostatin (mitochondrial protein with oncostatic activity), is a 498 amino acid protein that acts as a tumor suppressor which inhibits cell growth and has pro-apoptotic abilities during cell stress. Localizing to the cytoplasm, mitochondria and cell membrane, trichoplein is expressed at highest levels in breast epithelial cells, normal urothelial cells, skeletal muscle, liver, testis, heart and kidney. Trichoplein is also found in smooth muscle and endothelial cells, with low levels of expression in advanced bladder and breast carcinoma. Trichoplein interacts with Cytokeratin 5, 6, 8, 14, 16 and 18. A member of the THCP family, trichoplein is encoded by a gene that maps to human chromosome 12q24.11.
Description: Rabbit polyclonal to TCHP
Immunogen: KLH conjugated synthetic peptide derived from TCHP
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 61 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/100-500;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
