Background: Sodium-independent transporter of chloride and iodide. SLC26A4/Pendrin is an ion exchanger found in the cortical collecting duct. Pendrin is found at the luminal membrane of follicular cells in the thyroid gland. It transports iodine from the cytoplasm to the follicle lumen. Its activity is necessary for production of thyroid hormone.Pendrin is also found in the cells of the inner ear, where its function is not well understood. Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. Pendred syndrome is also characterized by hypothyroidism.
Description: Rabbit polyclonal to SLC26A4
Immunogen: KLH conjugated synthetic peptide derived from SLC26A4
Specificity: ·Reacts with Human and Mouse.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 86 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;
·Immunocytochemistry: 1/200;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
