Background: SETBP1 (SET binding protein 1) binds to the acute undifferentiated leukemia-associated protein SET. SETBP1 has an oncoprotein Ski homologous region (amino acids 654--858), six PEST sequences and three sequential PPLPPPPP repeats at the C-terminus. The function of SETBP1 is not known but possibly plays a key role in the mechanism of SET-related leukemogenesis and tumorigenesis, perhaps by suppressing SET function or by regulating the transforming activity of Ski in the nucleus. SETBP1 mRNA appears to be expressed ubiquitously in all human adult tissues and cells.
Description: Rabbit polyclonal to SETBP1
Immunogen: KLH conjugated synthetic peptide derived from SETBP1
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 170 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
