Background: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Interacts with VWF. VWF binding is essential for the stabilization of F8 in circulation. Secreted protein; extracellular space. Domain F5/8 type C 2 is responsible for phospholipid-binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A (HEMA). Belongs to the multicopper oxidase family.
Description: Rabbit polyclonal to FVIII
Immunogen: KLH conjugated synthetic peptide derived from FVIII
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 267 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
