Background: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. Endostatin is a fragment of the C-terminal domain NC1 of Collagen Type XV and Type XVIII that inhibits angiogenesis and tumor growth. Unlike endostatin-XVIII, endostatin-XV does not bind zinc or heparin, however both endostatins can inhibit chorioallantoic membrane angiogenesis induced by basic FGF or VEGF. Collagen Type XV and XVIII are also widely present in basement membrane zones, suggesting their roles in basement membrane-stromal interactions and involvement with angiogenic and pathological processes. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
Description: Rabbit polyclonal to Endostatin
Immunogen: KLH conjugated synthetic peptide derived from Endostatin
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 22 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
