Background: Mesothelin is a glycosylphosphatidylinositol-linked cell-surface molecule expressed in the mesothelial lining of the body cavities and in many tumor cells. Mesothelin is a tumor antigen on the surface of human ovarian cancers and mesotheliomas. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid, and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. In adult mouse tissues the mesothelin transcript is present in lung, heart, spleen, liver, kidney and testis.
Description: Rabbit polyclonal to Mesothelin
Immunogen: KLH conjugated synthetic peptide derived from Mesothelin
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 69 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
