Background: PRSS22 is a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. It preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. Tryptase ε, also known as brain-specific serine protease 4 (BSSP-4) or serine protease 22, is a member of the human 16p13.3 family of serine proteases. It is expressed in a developmentally regulated manner in esophagus, trachea and lung. Tryptase ε is a major product of the normal pulmonary epithelial cells. It is secreted as an active enzyme and, unlike other family members, Tryptase ε can autoactivate. Tryptase ε, once activated, cannot effectively be inhibited by the protease inhibitors that are found in normal plasma. It is a potent activator of uPA (urokinase-type plasminogen activator precursor), a serine protease that is responsible for cleaving plasminogen. Tryptase ε converts uPA into its mature, enzymatically active form and therefore plays an important role in fibrinolysis, connective tissue remodeling and innate immunity.
Description: Rabbit polyclonal to PRSS22
Immunogen: KLH conjugated synthetic peptide derived from PRSS22
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 34 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
