Background: MICB (MHC class I polypeptide-related sequence B) is a heavily glycosylated transmembrane protein expressed on the surface of cells in response to infection. It is distantly related to, but functionally distinct from MHC class I molecules. MICB is a stress induced ligand for the NKG2-D type II receptor found on natural killer (NK) cells, CD8+αβ T cells and γδ T cells. It activates the cytolytic response and is required for stimulating the host defense against virus-infected cells and tumor cells. MICB shares 91% identity with MICA. These proteins are stably expressed without conventional class I peptide ligands or association with β-2-microglobulin. MICA and MICB are predominantly expressed in epithelial cells, endothelial cells and fibroblasts and play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.
Description: Rabbit polyclonal to MICB
Immunogen: KLH conjugated synthetic peptide derived from MICB
Specificity: ·Reacts with Human.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 43 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
