Background: Originally isolated from osteoblastic cells, the TGF∫-inducible early gene-1 (TIEG1) is a Krupel-like zinc finger transcription factor that regulates cellular growth and differentiation. TIEG1 is regulated as an early response gene by TGF∫1. It is expressed in both acinar and ductular epithelial cells from exocrine pancreas and may serve as an early response gene in pancreatic cells, and overexpression of TIEG1 in TGF∫-sensitive epithelial cells induces apoptosis. TIEG1 is expressed at high levels in PBLs, spleen and colon, and at lower levels in thymus, small intestine, ovary, prostate and skeletal muscle. The nuclear TIEG2 protein, which shares significant homology with TIEG1, was originally isolated from globin-expressing human fetal erythroid cells. TIEG2 is expressed in fetal liver, and overexpression of TIEG2 in cultured epithelial cells inhibits cellular proliferation. TIEG2 expression is upregulated by TGF∫1 and serum deprivation.
Description: Rabbit polyclonal to FKLF
Immunogen: KLH conjugated synthetic peptide derived from FKLF
Specificity: ·Reacts with Human, Mouse and Rat.
.·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 56 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
