Background: Neu4 (N-acetyl-alpha-neuraminidase 4), also known as LP5125, is a 484 amino acid peripheral membrane protein that contains three BNR repeats and belongs to the glycosyl hydrolase 33 family. Expressed ubiquitously with highest expression in liver, Neu4 functions as a sialidase that catalyzes the hydrolysis of alpha-(2->3)-, alpha-(2->6)- and alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in synthetic substrates, as well as glycolipids, oligosaccharides and colominic acid. The gene encoding Neu4 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alström syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
Description: Rabbit polyclonal to NEU4
Immunogen: KLH conjugated synthetic peptide derived from NEU4
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 52 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
