Background: Endoplasmic reticulum proteins (ERps) are widely expressed proteins that localize to the ER and may act as proteases, protein disulfide isomerases, thiol-disulfide oxidases or phospholipases. ERp27 (endoplasmic reticulum protein 27 kDa), also known as C12orf46, is a 273 amino acid protein that contains one thioredoxin domain and, characteristic of ERps, localizes to the lumen of the endoplasmic reticulum. ERp27 lacks the CXXC active site that is necessary for catalytic activity and, therefore, functions as a non-catalytic disulfide iso-merase. Although ERp27 is catalytically inactive, it is thought to bind to and interact with ERp57 and Somatostatin. The gene encoding ERp27 localizes to human chromosome 12, which houses over 1,100 genes and comprises approximately 4.5% of the human genome.
Description: Rabbit polyclonal to ERP27
Immunogen: KLH conjugated synthetic peptide derived from ERP27
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 28 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
