Background: The regions of relatively constant sequence beyond the variable regions of Immunoglobulin are termed constant regions (C regions) and are present in both the heavy and light chains. With few exceptions, the sites of attachment for carbohydrates to immunoglobulin are located in the constant region. The constant regions also serve to hold the variable regions on both heavy and light chain together by virtue of the disulfide bond between them. The immunoglobulin J chain (Ig J chain) is a linker protein for two monomer units of either immunoglobulin alpha (IgA) or mu (IgM) polypeptides. For IgA the J chained-joined dimer induces larger polymers whereas for the IgM pentamer it functions as a nucleating unit. The Ig J-chain is also important in binding these immunoglobulins to secretory components.
Description: Rabbit polyclonal to Igj
Immunogen: KLH conjugated synthetic peptide derived from Igj
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 18 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
