Background: Secretoglobins (Lipophilins, Mammaglobins) are small secreted proteins of endocrine-responsive organs and mucosal epithelia that form multimeric complexes and correlate with the development of various human cancers. Lipophilin A (LIPA, LPHA, secretoglobin, family 1D, member 1; SCGB1D1) and Lipophilin B (LIPB, LPHB, secretoglobin, family 1D, member 2;SCGB1D2) are orthologs of prostatein (estramustine-binding protein), the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin A is a component of a heterodimeric molecule present in human tears. Lipophilin B mRNA can be overexpressed in breast tumors and shows a high degree of correlation with the mRNA expression profile of mammaglobin. Mammaglobin A (MGB1, secretoglobin, family 2A, member 2; SCGB2A2) and Mammaglobin B (MGB2, lipophilin C, LPHC, UGB3, SCGB2A2) histological detection in breast tissue is a reliable diagnostic marker for breast tumors.
Description: Rabbit polyclonal to Mammaglobin B
Immunogen: KLH conjugated synthetic peptide derived from Mammaglobin B
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 10 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.
