Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Cloning of complementary DNAs encoding adiponectin receptors 1 (AdipoR1) has shown that AdipoR1 is abundantly expressed in skeletal muscle. This receptor is structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1 or suppression of AdipoR1 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. Widely expressed. Highly expressed in skeletal muscle. ADR 1 is expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
脂聯素與受體結合后具有增強胰島素敏感性，抗高血糖，抗動脈粥樣硬化等生物學效應，任何增加或減少脂聯素及其受體表達的方法都影響這些疾病的發生和發展。脂聯素受體-1(AdipoR1和AdipoR2)同屬于PAQR家族，具有七次跨膜蛋白的特有結構。
我公司新研發的AdipoR1(脂聯素受體1)抗體已經通過檢驗測試，可以應用于蛋白印跡（WB），免疫組化（IHC），免疫細胞化學（ICC），酶聯免疫吸附試驗（ELISA），免疫沉淀（IP），免疫熒光（IF）實驗。具體信息如下：
編號 產品名稱
PR-1001， AdipoR1 Antibody
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鎮江厚普生物科技有限公司銷售部
2015-10-28