FKBP38 (FK506-binding protein 38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBP38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.
我公司新研發的FKBP38(FK506結合蛋白38)抗體已經通過檢驗測試，可以應用于蛋白印跡（WB），免疫組化（IHC），免疫細胞化學（ICC），酶聯免疫吸附試驗（ELISA），免疫沉淀（IP），免疫熒光（IF）實驗。具體信息如下：
編號 產品名稱
PR-1023， FKBP38 Antibody
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鎮江厚普生物科技有限公司銷售部
2015-10-28